The Effects Of Gemcitabine Resistance On Patients With...

Gemcitabine (2,2-diï ¬â€šuoro 2-deoxycytidine, dFdC) is a deoxycytdine analog; a prodrug with activity against non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), ovarian and pancreatic cancers (Hertel et al., 1990; Braakhuis et al., 1995; Boven et al.,1993; Merriman et al., 1996; Jansen et al., 1995) Pancreatic cancer tumor [1 2 ref]. Nowadays gemcitabine is signified as a single agent in the treatment of patients with metastatic pancreatic cancer [2], (2,2-diï ¬â€šuoro 2-deoxycytidine, dFdC) is an analogue of cytosine arabinoside (Ara-C) from which it vary structurally due to its ï ¬â€šuorine substituents on position 29of the furanose ring [ref 1]. Gemcitabine has a gold drug standard and has very similar activation step as of ara-C but with more complicated mechanism and with more cellular targets. Gemcitabine resistance is the biggest problem in the chemotherapy of cancer patients, alterations in the cellular target of the gemcitabine results in decreased sensitivity of the drug. There many factors involved in the resistance of gemcitabine and thus, a thus a thorough study is required for better understanding of the mechanisms determining its activation and development of resistance. This paper / article / review deals with the mechanisms involving pharmacology of gemcitabine. [ref 2 3] Gemcitabine Pharmacology: Transport / Uptake of Gemcitabine : Gemcitabine a nucleoside analogue is hydrophilic in nature and requires an active uptake through the cellShow MoreRelatedEffects Of Matrix Stiffness On Primary Pancreatic Cancer Cells734 Words   |  3 Pages3. Results (620-current730) 3.1 Softer substrate regulates proliferation of primary pancreatic cancer cells To study the effects of matrix stiffness on primary pancreatic cell proliferation, we first developed a 2D hydrogel system with stiffness (SSM) that mimic those of healthy pancreatic tissue and cancerous pancreas previously characterized. Briefly, the cancerous pancreatic tissue had a larger range of SSM (2kPa – 30kPa) and a higher average SSM than normal tissue (0.8 – 4 kPa). ConsequentlyRead MoreUnusual Presentation Of Metastatic Sebaceous Carcinoma2680 Words   |  11 PagesCASE REPORT Unusual presentation of metastatic sebaceous carcinoma and its response to chemotherapy: is genotyping a right answer for guiding chemotherapy in rare tumours? V. Kumar MD* and Y. Xu MD PhD†  METASTATIC SEBACEOUS CARCINOMA: PRESENTATION AND CHEMOTHERAPY, Kumar and Xu Correspondence to: Vivek Kumar, Department of Medicine, 4802 10th Avenue, Floor 3, Maimonides Medical Center, Brooklyn, New York 11219 U.S.A. E-mail: vivkumar@maimonidesmed.org :: DOI: http://dx.doi.org/10.3747/co.22.2467Read MoreNanotechnology and Natural Products as Novel Anti-cancer Therapy3247 Words   |  13 Pagesapproaches and agents against certain types of cancer that are urgently needed. Some of the new agents use highly advanced technology utilizing nanoencapsulation that will improve the therapeutic index of the natural drugs. Nanoparticles for cancer therapeutics are rapidly evolving and are being introduced in an attempt to overcome several limitations of conventional small-molecule chemotherapeutics. Though chemotherapy is successful to some extent in certain cancers, it has several limitations (14). I will